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 Vol. 12 No. 5, November 2004
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AAP Grand Rounds 12:53-54 (2004)
© 2004 American Academy of Pediatrics

NEPHROLOGY

Serum Uric Acid and Hypertension–Who Knew?

Source: Feig DI, Nakagawa T, Karamunchi SA, et al. Hypothesis: uric acid, nephron number and the pathogenesis of essential hypertension. Kidney Int. 2004;66:281–287.[Medline]

The first 20% of the full text of this article appears below.

In an informative and intriguing publication, the authors, from multiple institutions, sought to understand the relationships among uric acid, birth weight (BW), and maternal hypertension in children with hypertension. Using the database of the Hypertension Program at Texas Children’s Hospital, Houston, they retrospectively identified 95 children with new-onset primary hypertension. They analyzed family history, birth data (especially BW), and serum uric acid at the time of presentation with hypertension. The authors found that: 1) the mothers of children with primary hypertension were 1.5 to 4 times more likely to have hypertension than mothers of children with secondary hypertension, white coat hypertension, or normal . . . [Full Text of this Article]

Aaron L. Friedman, MD, FAAP
Pediatrics, Hasbro Children’s Hospital, Brown Medical School, Providence, RI

 





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