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 Vol. 13 No. 1, January 2005
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Right arrow Gastroenterology and Nutrition

AAP Grand Rounds 13:7 (2005)
© 2005 American Academy of Pediatrics

GASTROENTEROLOGY AND NUTRITION

Human Milk Oligosaccharides Protect Infants from Enteric Infection

Source: Morrow AL, Ruiz-Palacios GM, Altaye M, et al. Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. J Pediatr. 2004;145:297–303.[Medline]

The first 20% of the full text of this article appears below.

Researchers from Cincinnati Children’s Hospital Medical Center sought to determine whether variation in the concentration of oligosaccharides in human milk might explain why some breast-fed infants experience more episodes of diarrhea than others. Bioactive oligosaccharides are part of the innate defense system.1 The most common human milk oligosaccharides (HMOS) contain the sugar fucose.2 Expression of fucosolated oligosaccharides, including the 2- linked fucosyloligosaccharides (2-FOS), in human milk varies among mothers due to genetic factors.3 The authors analyzed frozen samples of breast milk collected from 1988–1991 from 93 breast-feeding Mexican mother-infant unit pairs who were followed from birth to 2 years post-partum. Milk samples obtained 1 to 5 weeks postpartum were analyzed for HMOS content and compared with the frequency of diarrhea from birth to 2 years of age as documented by trained field-workers. . . . [Full Text of this Article]

Mike Dubik, MD, FAAP1 and Leslie Barton, MD, FAAP2
1 Pediatrics, Naval Medical Center, San Diego, CA
2 Pediatrics, University of Arizona School of Medicine, Tucson, AZ

 



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