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 Vol. 13 No. 2, February 2005
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AAP Grand Rounds 13:22-23 (2005)
© 2005 American Academy of Pediatrics

INJURY AND POISON PREVENTION

Pediatric Poisonings: Know What Kills

Source: Michael JB, Sztajnkrycer MD. Deadly pediatric poisons: nine common agents that kill at low doses. Emerg Med Clin North Am. 2004;22:1019–1050.[Medline]

The first 20% of the full text of this article appears below.

Using data from the American Association of Poison Control Centers (AAPCC), the authors from the Mayo Clinic in Rochester, Minn, review 9 medications found to be fatal to children at low doses. Fortunately, the outcome in the vast majority of pediatric ingestions is nontoxic because only a small amount of the poison is consumed. This has led to the "one pill" rule, which postulates that a single adult therapeutic dose would not be expected to produce significant toxicity in a child. The authors identify 9 compounds that do not follow the "one pill" rule and can be fatal to children at low doses (Table 1Go). These compounds include prescription medications as well as over-the-counter preparations. Given the wide availability of these compounds and their high toxicity, it is essential for physicians to . . . [Full Text of this Article]

Gwen C. McIntosh, MD, MPH, FAAP1 and Murray L. Katcher, MD, PhD, FAAP2
1 Pediatrics, University of Wisconsin Medical School, Madison, WI
2 Pediatrics, University of Wisconsin Medical School, and Wisconsin Division of Public Health, Madison, WI

 





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