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This Article Full Text Full Text (PDF) Take the CME quiz: Vol. 13 No. 4, April 2005 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to My File Cabinet Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Spivack, B. Search for Related Content PubMed Articles by Spivack, B. Related Collections Child Abuse and Neglect

AAP Grand Rounds 13:44 (2005)
© 2005 American Academy of Pediatrics

Biochemical Brain Markers: Use in Diagnosis of Abusive Head Trauma?

The first 20% of the full text of this article appears below.

The authors from the Children’s Hospital of Pittsburgh present a review of biochemical markers of traumatic brain injury (TBI). Neuron specific enolase (NSE), S100B marker for astrocyte death, and myelin basic protein (MBP) levels were studied in 91 children with closed head injury of varying severity; 35 of these patients had suffered inflicted TBI. Control samples were obtained from children having blood drawn as part of routine well-child care or during treatment of acute, non-inflicted long bone fracture. The NSE was increased in 63% of children with TBI and inflicted TBI. S100B was increased in 37% of children with TBI and 41% of children with . . . [Full Text of this Article]

Betty Spivack, MD, FAAP

Pathology and Pediatrics, University of Louisville School of Medicine, and the Medical Examiner Division of the Kentucky Cabinet for Justice and Public Safety, Louisville, KY