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 Vol. 14 No. 4, October 2005
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AAP Grand Rounds 14:37-38 (2005)
© 2005 American Academy of Pediatrics

EPIDEMIOLOGY

Decline of Hepatitis A in the US: Another Vaccine Success Story

Source: Wasley A, Samandari T, Bell BP. Incidence of hepatitis A in the United States in the era of vaccination. JAMA. 2005;294:194–201.[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.

In the 1980s and 1990s, an average of 26,000 cases of hepatitis A was reported annually in the United States, with an estimated 270,000 infections per year when anicteric and asymptomatic cases were included.1 More than half of the infections occurred in children. In 1995, hepatitis A vaccine became available in the US. In 1999, routine vaccination was recommended for children living in 11 states with the highest incidence of hepatitis; vaccination was suggested for children living in 6 additional states with above-average rates of hepatitis A.2

Fundamental changes in the epidemiology of hepatitis A were detected in an analysis of national hepatitis A surveillance data by the Viral Hepatitis Division of the Centers for Disease Control and Prevention in Atlanta (CDC). Incidence rates of hepatitis A in . . . [Full Text of this Article]

Donald Schiff, MD, FAAP
University of Colorado School of Medicine and The Children’s Hospital, Denver, CO