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 Vol. 14 No. 4, October 2005
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AAP Grand Rounds 14:41 (2005)
© 2005 American Academy of Pediatrics

MEDICINE PEDIATRICS

Urine Tests for Detection of C trachomatis and N gonorrhoeae

Source: Cook RL, Hutchison SL, Ostergaard L, et al. Noninvasive testing for Chlamydia trachomatis and Neisseria gonorrhoeae. Ann Intern Med. 2005;142:914–925.[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.

Testing for sexually transmitted diseases poses several logistic barriers for the patient, including making an appointment with a provider and undergoing a pelvic examination with cultures or a urethral swab. The authors, from the University of Pittsburgh, performed a meta-analysis after searching 1991 to 2004 MEDLINE literature to locate all studies of urine testing using the currently available commercial nucleic amplification tests for Chlamydia trachomatis and Neisseria gonorrhoeae. The methodologies covered by these amplification tests included polymerase chain reaction (PCR), strand displacement amplification (SDA), and transcription-mediated amplification (TMA). The authors found 29 studies meeting the predetermined minimum standards, which included presenting data separately by gender, obtaining samples for the same assay on both urine and cervical or urethral sites, and using . . . [Full Text of this Article]

Brett Robbins, MD, FAAP
Pediatrics and Internal Medicine, University of Rochester, Rochester, NY