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AAP Grand Rounds 14:67-68 (2005) Longer Duration of Breastfeeding Decreases the Risk of OverweightSource: Harder T, Bergmann R, Kallischnigg G, et al. Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol. 2005;162:397403.
Researchers from Berlin, Germany, quantified the association between duration of breastfeeding and risk of childhood overweight in a meta-regression analysis. Using multiple methods, 49 articles initially were identified for the analysis. Only 17 articles met the inclusion criteria of being an original report comparing breastfed children with exclusively formula-fed children, reporting the odds ratio and 95 percent confidence interval (CI) of overweight or obesity (any definition was accepted) associated with breastfeeding, and reporting the duration of breastfeeding for at least 1 exposure group. The investigators also analyzed the data by different subgroups and checked for evidence of publication bias.
More than 100,000 children were subjects in the 17 studies. No publication bias was found. An inverse linear association was identified between duration of breastfeeding and risk of
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