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 Vol. 15 No. 2, February 2006
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AAP Grand Rounds 15:14-15 (2006)
© 2006 American Academy of Pediatrics

EPIDEMIOLOGY

Amoxicillin Use in Infancy and Enamel Defects in Permanent Teeth

Source: Hong L, Levy SM, Warren JJ, et al. Association of amoxicillin use during early childhood with developmental tooth enamel defects. Arch Pediatr Adolesc Med. 2005;159:943–948.[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.

Researchers from the University of Iowa recently reported an association between early amoxicillin use and enamel defects in primary molars.1 The same investigators examined the relationship between amoxicillin exposure in early childhood and enamel defects in permanent teeth. The Iowa Fluoride Study is a prospective epidemiological assessment of children’s dental health involving a convenience sample of 1390 subjects recruited at birth in Iowa hospitals in 1992–1995. Participants are predominantly white (98%) and of relatively high socioeconomic status. Amoxicillin exposure was ascertained from questionnaires mailed to families at 3- to 4-month intervals during the subjects’ first 32 months of life. Parents were asked to identify specific antibiotics given during each reporting period, including the route and duration of administration. Data were also collected on fluoride intake, illnesses, and breastfeeding.

The primary purpose of the ongoing study is to investigate dental "fluorosis," characterized by diffuse, white opacities on tooth enamel that . . . [Full Text of this Article]

Michael B. Aldous, MD, MPH, FAAP
Pediatrics, University of Arizona, Tucson, AZ

 





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