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 Vol. 15 No. 2, February 2006
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AAP Grand Rounds 15:20-21 (2006)
© 2006 American Academy of Pediatrics

CRITICAL CARE

Oxygenation Index Predicts Outcome of Acute Hypoxemic Respiratory Failure

Source: Trachsel D, McCrindle BW, Nakagawa S, et al. Oxygenation index predicts outcome in children with acute hypoxemic respiratory failure. Am J Respir Crit Care Med. 2005;172:206–211.[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.

Authors from The Hospital for Sick Children, Toronto reviewed data on all mechanically ventilated patients who required a positive end expiratory pressure (PEEP) ≥6 cm H2O and a FiO2 ≥0.5 for ≥12 hours to maintain adequate oxygenation. The authors sought to determine factors associated with prognosis for children with acute hypoxic respiratory failure and to analyze time-dependent risk of death and the utility of respiratory parameters for prognosis.

Patients with congenital or acquired heart disease, infants younger than 1 month, and those with severe neurological compromise were excluded. Data collection included demographic information, diagnosis and ventilator parameters, arterial blood gas measurements, measures of organ dysfunction, and Pediatric Risk of Mortality (PRISM) scores.1 Oxygenation failure was measured serially by assessing alveolar-arterial oxygen gradient (A-a)DO2, the PaO2/FiO2 (P/F) ratio, and the oxygenation index (OI) [OI = 100 x (FiO2 x MAP)/PaO2] every 12 hours after initiation of . . . [Full Text of this Article]

Kathleen M. Ventre, MD
Critical Care Medicine, Primary Children’s Medical Center, Salt Lake City, UT