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 Vol. 15 No. 2, February 2006
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AAP Grand Rounds 15:21-22 (2006)
© 2006 American Academy of Pediatrics

GASTROENTEROLOGY AND NUTRITION

Feeding Infants for Today and Growing Problems for Tomorrow?

Sources: (1) Barker DJ, Osmond C, Forsen TJ, et al. Trajectories of growth among children who have coronary events as adults. N Engl J Med. 2005;353:1802–1809.[Abstract/Free Full Text] (2) Stettler N, Stallings VA, Troxel AB, et al. Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation. 2005;111:1897–1903.[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.

Increasing evidence links low birth weight to coronary heart disease later in life,1–4 but the role of postnatal growth as a risk factor is uncertain. The authors of the first study (from the University of Southampton, United Kingdom, and the National Public Health Institute, Helsinki, Finland) used the records of 8760 people born in Helsinki to search for a link between postnatal growth and coronary heart disease. The subjects were all born at Helsinki University Central Hospital from 1934 through 1944 and attended child-welfare clinics in the city. A total of 357 men and 87 women had hospital admissions for coronary heart disease or had died from the disease. A subset of 2003 people was used to measure coronary risk factors. The authors analyzed how monthly changes in body size from birth to 2 years of age as well as annual changes through 11 years of age related to the subsequent development of coronary risk factors and coronary events.

The mean body size of children who had coronary events as adults was below average at birth. At 2 years of age, these children were thin, but subsequently their body mass index (BMI) increased progressively to that of other children and reached (or in the case of girls, exceeded) approximately average values . . . [Full Text of this Article]

Neal S. LeLeiko, MD, PhD, FAAP
Pediatrics and Pediatric Gastroenterology, Nutrition and Liver Disease, Brown School of Medicine and Hasbro Children’s Hospital, Providence, RI

 





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