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 Vol. 16 No. 4, October 2006
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Right arrow Weighing the Evidence

AAP Grand Rounds 16:39 (2006)
© 2006 American Academy of Pediatrics

RHEUMATOLOGY

Weighing the Evidence: Can We Believe an Open-Label Study?

Bernhard L. Wiedermann, MD, FAAP
The first 20% of the full text of this article appears below.

For treatment studies, blinding of intervention is considered optimal to avoid bias in assessing outcomes. Ideally, both the patient (and his/her family) and the caregivers (including anyone responsible for assessing outcomes) are blinded; this is termed a double-blind study. However, sometimes this is difficult or even impossible. Studies involving a surgical vs medical intervention could not be blinded easily for . . . [Full Text of this Article]