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 Vol. 17 No. 5, May 2007
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AAP Grand Rounds 17:50-51 (2007)
© 2007 American Academy of Pediatrics

INFECTIOUS DISEASE

Re-Immunization After Treatment of Leukemia

Source: Patel SR, Ortin M, Cohen BJ, et al. Revaccination of children after completion of standard chemotherapy for acute leukemia. Clin Infect Dis. 2007;44:635–642; doi: 10.1086/5116h36[Medline]

The first 20% of the full text of this article appears below.

Investigators from three United Kingdom institutions in Sutton, London, and Manchester evaluated the vaccine-specific antibody persistence and immunogenicity of five childhood vaccines (MMR, tetanus toxoid, IPV, Hib conjugate, and meningococcus C [MCC]) after completion of chemotherapy for acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). Fifty-nine previously vaccinated children ages 1–18 years who had completed treatment for ALL or AML at least six months earlier were enrolled over a two-year period. Patients were revaccinated with one dose each of DTaP, IPV, Hib, Measles (administered as MMR), and MCC. Blood samples for serologic testing were obtained on the day of vaccination, at two to four weeks, and one year later. For each of the five vaccines, there was a significant rise in the antibody level after revaccination. There was no statistical association for any of the five . . . [Full Text of this Article]

Hemophilus b:
Tetanus, polio:
Measles:
Meningococcal vaccine:
Mobeen Rathore, MD, FAAP1 and Leslie L. Barton, MD, FAAP2
1 Pediatric Infectious Diseases and Immunology, University of Florida and Wolfson Children’s Hospital, Jacksonville, Florida
2 Pediatrics, University of Arizona, Tucson, AZ

 



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