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 Vol. 19 No. 1, January 2008
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AAP Grand Rounds 19:3-4 (2008)
© 2008 American Academy of Pediatrics

CRITICAL CARE

Hypothermia to Treat Neonatal Hypoxic Ischemic Encephalopathy

Source: Shah P, Ohlsson A, Perlman M. Hypothermia to treat neonatal hypoxic ischemic encephalopathy. Arch Pediatr Adolesc Med. 2007;161(10):951–958[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: Among neonates with hypoxic ischemic encephalopathy, does treatment with hypothermia, compared to normothermia, result in improved neurodevelopmental outcomes?

Question type: Intervention (therapy)

Study design: Systematic review of randomized trials

 

The authors from Mount Sinai Hospital and the University of Toronto performed a metaanalysis of studies using hypothermia in the treatment of asphyxiated neonates to prevent death and enhance survival without moderate to severe disability.

Randomized and quasi-randomized controlled studies of hypothermia (systemic and selective head cooling) were included. Four studies that used systemic hypothermia and four that used selective head cooling were evaluated. The intervention occurred within six hours of birth in all studies. The degree of targeted hypothermia varied from 33.0 to 34.5°C and the duration of therapy varied from 48 hours (single study) to 72 hours (seven studies).

For the primary outcome, survival without . . . [Full Text of this Article]

Kimberly D. Statler, MD, FAAP
Pediatric Critical Care Medicine, University of Utah, Salt Lake City, UT

 



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M. Zebrack
Hypothermia for Traumatic Brain Injury
AAP Grand Rounds, September 1, 2008; 20(3): 28 - 29.
[Full Text] [PDF]


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