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 Vol. 19 No. 1, January 2008
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AAP Grand Rounds 19:4 (2008)
© 2008 American Academy of Pediatrics

SENIOR MEMBERS/INFECTIOUS DISEASES

Multiresistant Pneumococci in Otitis Media

Source: Pichichero ME, Casey JR. Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children. JAMA. 2007;298(15):1772–1778; doi:10.1001/jama.298.15.1772[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: Among children with acute otitis media due to Streptococcus pneumoniae, does exposure to PCV7-vaccine result in a greater likelihood of antimicrobial-resistant organisms?

Question type: Descriptive

Study design: Prospective cohort, observational study

 

Within three years of the introduction of a pneumococcal 7-valent conjugate vaccine (PCV7) in 2000, reports began to appear of increasing isolation of non-PCV7 serotypes of pneumococci from children with both invasive disease and otitis media.1,2

Investigators from the University of Rochester and the Legacy Pediatrics practice group prospectively monitored Streptococcus pneumoniae serotypes and antibiotic susceptibility following the introduction of PCV7 vaccine.

Two populations of healthy six-to 36-month-old children from a suburban private practice were monitored during three consecutive respiratory illness seasons from 2003–2006. The first group consisted of children who were having their first or second episode of acute otitis media (AOM) in their life and the second included children with recurrent AOM or with treatment failures. The diagnosis of AOM was made using AAP criteria.1 S. . . . [Full Text of this Article]

Donald Schiff, MD, FAAP
University of Colorado School of Medicine and The Children’s Hospital, Denver, CO

 





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