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 Vol. 19 No. 1, January 2008
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AAP Grand Rounds 19:9-10 (2008)
© 2008 American Academy of Pediatrics

NEPHROLOGY

Diagnosing Hypercalciuria: A Rocky Road

Source: Royun M, Güven AG, Filiz S, et al. Screening for hypercalciuria in school children: what should be the criteria for diagnosis? Pediatr Nephrol. 2007;22(9):1297–1301; doi:10.1007/s00467–007–0528–9[CrossRef][Medline]

The first 20% of the full text of this article appears below.


PICO

Question: Among children with suspected hypercalciuria, does Ca/Cr ratio accurately reflect 24-hour urinary calcium?

Question type: Diagnostic test

Study Design: Comparison with gold standard

 

Researchers from Akdeniz University in Turkey sought to assess the correlation between urinary calcium:creatinine ratio (UCa/Cr) and 24-hour urinary calcium excretions and to determine the reference values of the UCa/Cr ratio in school-aged children.

Nonfasting, second morning urine samples were collected in children from 14 elementary schools over a five-month period. Children with a chronic disease or who were on medication were excluded.

Children with UCa/Cr ≥ 0.21 (mg/mg) were defined as having suspected hypercalciuria and had 24-hour urine samples collected. Children with a daily urinary calcium excretion ≥ . . . [Full Text of this Article]

Aaron L. Friedman, MD, FAAP
Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI

 





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