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 Vol. 19 No. 4, April 2008
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AAP Grand Rounds 19:42-43 (2008)
© 2008 American Academy of Pediatrics

RHEUMATOLOGY

Cognitive Problems in Children With Systemic Lupus

Source: DiFrancesco MW, Holland SK, Ris MD, et al. Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus. Arthritis Rheum. 2007;56(12):4151–4163; doi:10.1002/art.23132[CrossRef][Medline]

The first 20% of the full text of this article appears below.


PICO

Question: Do children with SLE have different patterns of brain activation during neuropsychological testing, compared with healthy children?

Question type: Prognosis

Study Design: Case control study

 

The authors from the Cincinnati Children’s Hospital Medical Center explored the use of functional magnetic resonance imaging (FMRI) for evaluating neuropsychiatric involvement in systemic lupus erythematosus (NPSLE). FMRI detects changes in blood hemoglobin oxygenation, and it has been used to evaluate cognitive function in various diseases.

Patients were trained in three cognitive tasks prior to undergoing FMRI. The tasks included language assessment (generate verbs related to given noun), attention assessment (identify when a digit is consecutively repeated), and working memory assessment (identify the number shown two previous to currently shown number). Control tasks that did not require the same cognitive functions included motor activities such as tapping a finger, repeatedly pressing a control button, or pressing the number currently displayed. FMRI scans taken while performing these tasks were compared with FMRI studies of healthy controls performing the same cognitive tasks.

Ten female patients with childhood-onset SLE were studied. Six patients had cognitive dysfunction diagnosed by neurocognitive . . . [Full Text of this Article]

Suzanne C. Li, MD, PhD, FAAP
Pediatrics, Joseph M. Sanzari Children’s Hospital, HUMC, Hackensack, NJ

 





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