AAP Grand Rounds Subscribe to Pediatrics in Review
HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Take the CME quiz:
 Vol. 19 No. 4, April 2008
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Millichap, J. G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Millichap, J. G.

AAP Grand Rounds 19:44-45 (2008)
© 2008 American Academy of Pediatrics

NEUROLOGY

Developmental Outcome of Very Preterm Infants Correlates with Grey and White Matter Abnormalities

Source: Nosarti C, Giouroukou E, Healy E, et al. Grey and white matter distribution in very preterm adolescents mediates neurodevelopmental outcome. Brain. 2008;131:205–217; doi:10.1093/brain/awm282[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: Among adolescents born very preterm, do white and grey matter changes seen on MRI in adolescence correlate with neonatal imaging studies and predict developmental outcome?

Question type: Prognosis

Study design: Retrospective

 

Because preterm infants often experience cognitive difficulties through adolescence,1 investigators from King’s College, London, sought to determine if adolescents who were born very preterm (VPT) would show diffuse white matter (WM) and grey matter (GM) abnormalities, especially in the prefrontal and temporal cortices. Such abnormalities could be a possible explanation for the cognitive deficits observed in VPT populations.

MRI data of brains of 218 adolescents (ages 14–15 years) who were born at <33 weeks gestation (VPT) and 128 controls born at term were compared using voxel-based morphometry, and the findings correlated with neurodevelopmental outcomes. Voxel-based morphometry is a neuroimaging analysis technique applied to structural MRI imaging that allows for calculation of focal brain volumes.

VPT study participants had been born at a mean gestational age of 29 weeks and had a mean birth weight of 1,276 grams; . . . [Full Text of this Article]

J. Gordon Millichap, MD, FAAP
Neurology, Children’s Memorial Hospital, Northwestern University Medical School, Chicago, IL

 





HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Academy of Pediatrics.