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AAP Grand Rounds 2:8-9 (1999)
© 1999 American Academy of Pediatrics

Effects of Inhaled Nitric Oxide Therapy on Gas Exchange

The first 20% of the full text of this article appears below.

One hundred and eight children with hypoxic respiratory failure were enrolled at 7 study centers. The children were randomized to receive inhaled nitric oxide (iNO) at 10 ppm or mechanical ventilation alone for a minimum of 72 hours. The oxygenation index (OI) was followed and an OI >= 40 for 3 hours or an OI >= 25 for 6 hours were considered treatment failures and the study terminated. Twice as many children in the control group were immunocompromised (33% vs. 17%), and they also had a larger proportion with chronic lung disease (27% vs 17%). Comparisons of OI’s during the first 12 hours of the study demonstrated an improvement in oxygenation in the . . . [Full Text of this Article]

Susan L. Bratton, MD, FAAP

Critical Care Medicine, Pediatrics, Oregon Health Sciences University, Portland, OR