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AAP Grand Rounds 2:19-20 (1999)
© 1999 American Academy of Pediatrics

ENDOCRINOLOGY

Pregnancies and Offspring of Women with Congenital Adrenal Hyperplasia

Source: Lo JC, Schwitzgebel VM, Tyrrell JB, et al. Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab. 1999;84:930–936.[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.

Very few women with salt-losing congenital adrenal hyperplasia conceive and bear children, although the reasons are not clear. This report describes maternal serum steroid hormone levels during gestation and the pregnancy outcome in 4 women with classic congenital adrenal hyperplasia (CAH; 21-hydroxylase deficiency), 3 with the salt-losing form and one with the non-salt-losing form. All 3 with the salt-losing form presented with pseudohermaphrodism requiring genital reconstruction or vaginoplasty. During their pregnancies all 4 patients were provided adrenal steroid hormone replacement according to standard clinical management procedures. Hormonal androgen levels increased throughout gestation in all 4 women, but . . . [Full Text of this Article]

Kenneth Copeland, MD, FAAP
Pediatrics, Baylor College of Medicine, Houston, TX