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AAP Grand Rounds 2:20-21 (1999)
© 1999 American Academy of Pediatrics

NEPHROLOGY

Genes, Salt and Blood Pressure

Source: Wong ZY, Stebbing M, Ellis JA, Lamantia A, Harrap SB. Genetic linkage of beta and gama subunits of epithelial sodium channel to systolic blood pressure. Lancet. 1999;353:1222–1225.[Medline]

The first 20% of the full text of this article appears below.

Two hundred and eighty-six Caucasian families from Victoria, Australia, comprised of both parents and two natural children (ages 18–30 including 32 dizygotic twin pairs) were genotyped at chromosome 16p12. Genomic DNA was analyzed for genes on chromosome 16p12 which code for the beta and gamma subunits of two epithelial sodium channels, SCNNIB and SCNNIG respectively. These genes previously have been shown to be linked with sodium dependent forms of low and high blood pressure. Systolic blood pressure is influenced by pulse pressure which, in turn, reflects left-ventricular stroke volume, the compliance of larger arteries, and reflected pulse waves. . . . [Full Text of this Article]

Alan Gruskin, MD, FAAP
Nephrology, Children’s Hospital of Michigan, Detroit, MI