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AAP Grand Rounds 2:28 (1999)
© 1999 American Academy of Pediatrics

SURGERY

The Role of ECMO in Neonates with CDH

Source: The Congenital Diaphragmatic Hernia Study Group. Does extracorporeal membrane oxygenation improve survival in neonates with congenital diaphragmatic hernia? J Ped Surg. 1999;34(5):720–724; discussion 724–725.

The first 20% of the full text of this article appears below.

While the benefit from extracorporeal membrane oxygenation (ECMO) in improving survival of neonates with congenital diaphragmatic hernia (CDH) has never been clearly demonstrated with a randomized controlled trial, the lack of alternative therapy and the high mortality rate (approximately one-third) has led to widespread use of this aggressive and costly therapy. This study analyzes data from a CDH registry involving 65 centers with and without ECMO capability to determine if ECMO improved survival after adjusting for overall risk of mortality. Data were available for 632 neonates with birth weight (BW) >2kg, of whom 289 received ECMO. Patients were divided into quintiles based on their . . . [Full Text of this Article]

Kevin Lally, MD, FAAP
Surgery and Pediatrics, University of Texas, Houston, TX