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AAP Grand Rounds 2:30-31 (1999)
© 1999 American Academy of Pediatrics

NEUROLOGY

Elevated Cytokines and Cerebral Palsy

Source: Grether JK, Nelson KB, Dambrosia JM, Phillips TM. Interferons and cerebral palsy. J Pediatr. 1999;134:324–332.

The first 20% of the full text of this article appears below.

In a retrospective study, Grether et al investigated the association between spastic cerebral palsy (CP) and serum levels of neonatal interferons (IFNs), other inflammatory cytokines, thyroid hormones, complement and coagulation factors. The subjects were selected from a population based case-control study of CP risk factors conducted in the San Francisco area between 1983 and 1985. One hundred and ninety-two children were identified with CP at 3 years of age. From this group, a subset of children with moderate to severe spastic CP was selected based upon the availability of archived blood from newborn metabolic screening and neonatal exposure to intrauterine infection, asphyxia or maternal problems in the second half of pregnancy. Also included was a small group of children with no apparent cause for their CP. The final study cohort included 31 mostly term children with spastic CP for whom . . . [Full Text of this Article]

Ulana M. Sanocka, MD
Columbia University, Division of Neonatology, Babies & Children’s Hospital of New York, New York, NY