This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gruskin, A. B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Gruskin, A. B.
Related Collections
Right arrow Genetics, Birth Defects
Right arrow Nephrology

AAP Grand Rounds 2:55 (1999)
© 1999 American Academy of Pediatrics

GENETICS, BIRTH DEFECTS

Molecular Genetics Used to Predict Renal Damage in Congenital Uropathies

Source: Hohenfellner K, Hunley TE, Brezinska R, et al. ACE I/D gene polymorphism predicts renal damage in congenital uropathies. Pediatr Nephrol. 1999;13:514–518.

The first 20% of the full text of this article appears below.

Children with various types of congenital uropathies are known to experience different outcomes despite early diagnosis and aggressive therapy. This study evaluated whether the insertion or deletion (I/D) of a 287 base pair fragment of the human angiotensin converting enzyme (ACE) gene is a risk factor for renal parenchymal damage in 162 Caucasian patients (163 Caucasian controls) with ureteral pelvic junction obstruction (n=49), primary megaureter (n=19), vesicoureteral reflux (n=67), and posterior urethral valves (n=27). This particular I/D modulates circulating and tissue ACE activities that have been linked to progression of cardiovascular and renal diseases. The distribution of the ACE I/D genotype was similar in the . . . [Full Text of this Article]

Alan B. Gruskin, MD, FAAP
Children’s Hospital of Michigan, Detroit, MI