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AAP Grand Rounds 2:58 (1999)
© 1999 American Academy of Pediatrics

INFECTIOUS DISEASES

Congenital LCMV Infection: A Cause of Hydrocephalus and Chorioretinitis

Source: Enders G, Varho-Göbel M, Löhler J, et al. Congenital lymphocytic choriomeningitis virus (LCMV) infection: an underdiagnosed disease. Ped Inf Dis J. 1999;18:652–655.

The first 20% of the full text of this article appears below.

Enders and colleagues describe 6 children infected in utero with lymphocytic choriomeningitis virus (LCMV). This agent is in the Arenaviridae family and its reservoir is rodents, particularly mice and hamsters. Acquired human infection generally manifests as fever, headache, nausea, myalgia, meningitis, or meningoencephalitis. Fetal infection in the first trimester of pregnancy has been associated with spontaneous abortions, and in the second and third trimesters with intrauterine death, hydrocephalus, and chorioretinitis. This report presents clinical and serologic data from 6 German children (including 1 in utero death and a set . . . [Full Text of this Article]

Leslie L. Barton, MD, FAAP
Pediatrics and Pediatric Infectious Diseases, University of Arizona, Tucson, AZ