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 Vol. 20 No. 1, July 2008
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Right arrow Weighing the Evidence

AAP Grand Rounds 20:2 (2008)
© 2008 American Academy of Pediatrics

EPIDEMIOLOGY

Weighing the Evidence: How Safe is Safe? Understanding Zero Numerators

Michael Aldous, MD, MPH, FAAP
The first 20% of the full text of this article appears below.

A therapy or intervention is often reported to be safe based on a study in which a group of subjects receives the intervention and does not experience adverse effects. The absence of observed complications is intuitively reassuring, but such reassurance is not always justified.

When an adverse effect does not occur among a group of n subjects, we can estimate the rate of the adverse . . . [Full Text of this Article]


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