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AAP Grand Rounds 20:5-6 (2008)
© 2008 American Academy of Pediatrics
| The first 20% of the full text of this article appears below. |
| PICO Question: Among infants with congenital CMV infection, what are the incidence, characteristics and course of sensorineural hearing loss? Question type: Prognosis Study design: Descriptive
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To determine the incidence, characteristics, and evolution of sensorineural hearing loss (SNHL) in infants with congenital cytomegalovirus infection (cCMV), Belgian investigators prospectively screened 14,021 neonates for cCMV infection between June 1996 and November 2006.
Mothers were screened by serologic testing during pregnancy and infants by a urine culture within seven days of birth. Maternal CMV infection was categorized as primary if seroconversion occurred during pregnancy or if the initial tests showed high IgM antibodies against CMV and low IgG antibodies, and subsequent titers demonstrated a decrease in IgM antibodies and increase
| Pediatric Infectious Diseases and Immunology, University of Florida College of Medicine, Jacksonville and Wolfson Childrens Hospital, Jacksonville, FL |
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