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 Vol. 20 No. 2, August 2008
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AAP Grand Rounds 20:20 (2008)
© 2008 American Academy of Pediatrics

HEMATOLOGY-ONCOLOGY

Cognitive Function Following Stem Cell Transplant in Childhood

Source: Phipps S, Rai SN, Leung WH, et al. Cognitive and academic consequences of stem-cell transplantation in children. J Clin Oncol. 2008; 26(12):2027–2033; doi: 10.1200/JCO.2007.13.6135[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: Is neurocognitive development impaired in children who undergo stem cell transplantation?

Question type: Prognosis

Study design: Prospective cohort

 

Investigators from St. Jude Children’s Research Hospital sought to prospectively describe cognitive and academic outcomes in survivors after pediatric hematopoietic stem-cell transplantation (SCT).

All patients undergoing SCT were eligible for the study, except for those with brain tumors or those for whom English was not their primary language. Patients were administered a battery of neurocognitive tests before transplant and then one, three, and five years later.

From 1991 to 1999, 268 patients were enrolled. Of these, 158 who were alive one year after SCT and completed at least one posttransplant assessment comprised the study cohort. Prior to SCT the estimated . . . [Full Text of this Article]

Anthony D. Villella, MD, FAAP
Pediatric Hematology/Oncology, Case Western Reserve University, Rainbow Babies & Children’s Hospital, Cleveland, OH