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 Vol. 20 No. 3, September 2008
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AAP Grand Rounds 20:31 (2008)
© 2008 American Academy of Pediatrics

GENETICS

Genetic Variation in Serotonin Metabolism and SIDS

Source: Marzano FN, Maldini M, Filzoni L, et al. Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. Genomics. 2008; 91(6):485–491; doi:10.1016/j.ygeno.2008.01.010.[CrossRef][Medline]

The first 20% of the full text of this article appears below.


PICO

Question: Are genetic polymorphisms in the genes controlling serotonin more common among SIDS victims than among healthy children?

Question type: Prognosis

Study design: Case series

 

To determine the possible contribution of genetic factors to sudden infant death syndrome (SIDS) Italian investigators studied the genotypes and allelic frequencies of genes controlling serotonin synthesis, release regulation, reuptake, and metabolism in brain-stem samples from infants dying from SIDS and whole-blood samples from healthy controls.

SIDS victims were identified according to pathologic and forensic criteria. Polymorphisms in the TPH2, 5-HTTLPR, 5-HTT (SLC6A4) intron 2 variable-number tandem repeat (VNTR), and the MAOA VNTR regions were determined. Two allelic variants (S and L) . . . [Full Text of this Article]

Kimberly Iafolla, MD, FAAP
Genetics and Birth Defects, Shady Grove Adventist Hospital, Rockville, MD