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 Vol. 20 No. 4, October 2008
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AAP Grand Rounds 20:40 (2008)
© 2008 American Academy of Pediatrics

HOSPITAL CARE

Features of Neonatal Herpes Simplex Virus Infection

Source: Caviness AC, Demmler GJ, Selwyn BJ. Clinical and laboratory features of neonatal herpes simplex virus infection. A case-control study. Pediatr Infect Dis J. 2008;25(5):425–430; doi:10.1097/INF.0b013e3181646d95

The first 20% of the full text of this article appears below.


PICO

Question: What are the clinical and laboratory features of neonates with herpes simplex virus infection admitted to the hospital?

Question type: Descriptive

Study design: Retrospective, case control

 

In this retrospective, case-controlled study, researchers from Texas Children’s Hospital (TCH) compared the clinical and laboratory features of neonates with HSV infection to similar patients without HSV infection.

Neonates hospitalized between July 1991 and December 2005 at TCH who underwent testing to identify HSV infection were eligible for inclusion. Neonates were classified as having HSV infection if they had both 1) virologic confirmation of HSV infection and 2) HSV infection confirmed in the review of their medical record. HSV infection was characterized as disseminated, central nervous system (CNS), or skin, eye, and mouth disease (SEM). The comparison group was made up of four neonates without HSV infection admitted within four weeks . . . [Full Text of this Article]

Brian Pate, MD, FAAP
Pediatric Hospital Medicine, Children’s Mercy Hospital, Kansas City, MO