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 Vol. 20 No. 4, October 2008
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AAP Grand Rounds 20:40-41 (2008)
© 2008 American Academy of Pediatrics

EMERGENCY MEDICINE

Oral Ondansetron Reduces Need for IV Fluids in Gastroenteritis

Source: Roslund G, Hepps TS, McQuillen KK. The role of oral ondansetron in children with vomiting as a result of acute gastritis/gastroenteritis who have failed oral rehydration threrapy: a randomized controlled trial. Ann Emerg Med. 2008;52(1):22–29; doi:10.1016/j.annemergmed.2007.09.010[CrossRef][Medline]

The first 20% of the full text of this article appears below.


PICO

Question: Among children aged 1–10 years with vomiting from acute gastritis/gastroenteritis who fail oral rehydration, does treatment with oral ondansetron compared to placebo reduce the need for intravenous fluids and admission to the hospital?

Question type: Intervention

Study design: Prospective, randomized, controlled clinical trial

 

Oral rehydration fluids are the recommended therapy for mild to moderate dehydration from acute gastroenteritis and acute gastritis.1 Despite these national recommendations, emergency departments (EDs) commonly use intravenous fluid therapy (IVT) for the treatment of moderate dehydration, especially in patients with persistent emesis.

Researchers from the ED at Advocate Christ Medical Center in suburban Chicago, IL, investigated the potential benefit of treatment with oral ondansetron, an antinausea agent, in patients with mild to moderate dehydration from suspected gastritis or gastroenteritis and persistent emesis.

Investigators enrolled a convenience sample of patients aged 1–10 years if they failed a standardized oral rehydration treatment (ORT) . . . [Full Text of this Article]

Ronald I. Paul, MD, FAAP
Pediatric Emergency Medicine, University of Louisville, Louisville, KY