This Article Full Text Full Text (PDF) Take the CME quiz: Vol. 20 No. 4, October 2008 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to My File Cabinet Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Millichap, J. G. PubMed Articles by Millichap, J. G.

AAP Grand Rounds 20:45-46 (2008)
© 2008 American Academy of Pediatrics

Brain Injury and Developmental Outcome After Symptomatic Neonatal Hypoglycemia

The first 20% of the full text of this article appears below.

PICO Question: Among term and near-term neonates with symptomatic hypoglycemia, do brain injury patterns identified on early MRI scans predict neurodevelopmental outcome? Question type: Prognosis Study design: Retrospective review

 

Brain injury patterns on early MRI and neurodevelopmental outcome after symptomatic neonatal hypoglycemia were studied in 35 term infants at Hammersmith Hospital, Imperial College London, UK.

Study infants were born at 36 weeks gestation or later, had at least one documented episode of hypoglycemia (blood or plasma glucose concentration of <2.6 mmol/L) associated with acute neurologic dysfunction during the first postnatal week, and had an MRI at postnatal age of <6 weeks.

Exclusion criteria included congenital infections, major brain or other malformations, multiple dysmorphic features, chromosomal abnormalities, and evidence of hypoxic-ischemic encephalopathy. Perinatal history was compared with data from 229 neurologically normal term infant controls. Outcome was assessed at a minimum of 18 months.

A total of 35 infants were studied. The median glucose level during hypoglycemic . . . [Full Text of this Article]

J. Gordon Millichap, MD, FAAP

Neurology, Children’s Memorial Hospital, Northwestern University Medical School, Chicago, IL