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 Vol. 21 No. 1, January 2009
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AAP Grand Rounds 21:6 (2009)
© 2009 American Academy of Pediatrics

CRITICAL CARE

Risk of Death After Hematopoietic Stem Cell Transplantation

Source: van Gestel JPJ, Bollen CW, van der Tweel I, et al. Intensive care unit mortality trends in children after hematopoietic stem cell transplantation: a meta-regression analysis. Crit Care Med. 2008;36(10):2898–2904; doi:10.1097/CCM.0b013e318186a34a[Medline]

The first 20% of the full text of this article appears below.

The objective of the current study was to analyze intensive care unit (ICU) mortality trends and the main prognostic factors associated with hospital death in pediatric hematopoietic stem cell transplantation (HSCT, also known as bone marrow transplant) recipients.


PICO

Question: Have mortality rates changed for children who require intensive care unit care after hematopoietic stem cell transplantation?

Question type: Prognosis

Study design: Systematic review with meta-regression

 

Need for ICU care after HSCT has historically been associated with high mortality rates. Whether ICU mortality for HSCT recipients has improved with better support methods is controversial.1–3

Investigators from the Wilhelmina Children’s Hospital and Utrecht University in the Netherlands performed a comprehensive literature search in articles published through August 2006 on ICU mortality trends following HSCT and factors associated with death. Because of the heterogeneity of reported . . . [Full Text of this Article]

Susan L. Bratton, MD, MPH, FAAP
Pediatric Critical Care Medicine, Primary Children’s Medical Center, University of Utah Health Sciences Center, Salt Lake City, UT