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 Vol. 22 No. 1, July 2009
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AAP Grand Rounds 22:3 (2009)
© 2009 American Academy of Pediatrics

NEUROLOGY

Risk Factors for Epilepsy After Traumatic Brain Injury

Source: Christensen J, Pedersen MG, Pedersen CB, et al. Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study. Lancet. 2009;373(9669):1105–1110; doi:10.1016/S0140-6736(09)60214-2[CrossRef][Medline]

The first 20% of the full text of this article appears below.


PICO

Question: Among children who have incurred traumatic brain injury, what is the risk of epilepsy and how long does the increased risk last?

Question type: Prognosis

Study design: Population-based cohort study

 

Investigators from the University of Aarhus, Aarhus, Denmark, sought to define the risk of epilepsy up to 10 or more years after traumatic brain injury (TBI) in a population-based cohort study. Data from the Danish Civil Registration System were used to identify 1,605,216 people born in Denmark between 1977 and 2002. Information about brain injury and epilepsy was obtained from the Danish National Hospital Register which contains information on all discharges from Danish hospitals since 1977. Brain injury was classified as "mild" ("concussion," loss of consciousness <30 min, amnesia <24 hrs, confusion/disorientation, or focal [temporary] neurological deficit), "severe" (structural brain injury), or skull fracture.

Between 1977 and 2002, 78,572 people were identified with at least one TBI. In the same time period, 17,470 people developed epilepsy, of whom 1,017 . . . [Full Text of this Article]

J. Gordon Millichap, MD, FAAP
Neurology, Children’s Memorial Hospital, Northwestern University Medical School, Chicago, IL