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 Vol. 22 No. 1, July 2009
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AAP Grand Rounds 22:9 (2009)
© 2009 American Academy of Pediatrics

COMMUNITY PEDIATRICS

Male Circumcision Associated With Reduced Risk of HSV-2 and HPV

Source: Tobian AR, Serwadda D, Quinn TC, et al. Male circumcision for the prevention of HSV-2 and HPV infection and syphilis. N Engl J Med. 2009;360(13):1298–1309; doi:10.1056/ NEJMoa0802556[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: Among males aged 15 to 49 years, does circumcision help to prevent HSV-2, HPV, or syphilis infections?

Question type: Intervention

Study design: Randomized trial

 

This collaboration of authors from the Johns Hopkins University, the National Institutes of Health, the Makerere University in Kampala, and the Rakai Health Sciences Program in Entebbe, Uganda sought to determine if male circumcision significantly reduced the incidence of herpes simplex virus type 2 (HSV-2), human papillomavirus (HPV) infections, and syphilis in HIV-negative adolescent boys and men between the ages of 15 and 49 years.

A total of 5,534 adolescent boys and men were enrolled in two . . . [Full Text of this Article]

Fredric T. Serota, MD, JD
Ambler Pediatrics, Ambler, PA