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 Vol. 22 No. 5, November 2009
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AAP Grand Rounds 22:52 (2009)
© 2009 American Academy of Pediatrics

NEUROLOGY

Cognitive Impairments at Onset of Epilepsy

Source: Fastenau PS, Johnson CS, Perkins SM, et al. Neuropsy- Neuropsychological status at seizure onset in children. Risk factors for early cognitive deficits. Neurology. 2009;73(7):526–534; doi:10.1212/WNL.0b013e3181b23551[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: Among children with a first unprovoked seizure, what cognitive deficits exist?

Question type: Prognosis

Study design: Prospective cohort study

 

Investigators from Indiana University, Indianapolis, and Case Western Reserve, Cleveland, OH, conducted a prospective cohort study to characterize neuropsychological functioning and academic achievement among children at the time of a first recognized seizure. Children between 6 and 14 years of age with an IQ of at least 70 were recruited between 2000 and 2004 at two academic medical centers and through practicing physicians and school nurses throughout Indiana within three months of a first-recognized unprovoked seizure. Controls consisted of healthy siblings between 6 and 18 years of age. Neuropsychological testing included four domains (language, processing speed, verbal memory and learning, attention/executive/construction) and a deficit was defined as 1.3 SD below the sibling norm (10th percentile).

A total of 282 children, with a mean age of . . . [Full Text of this Article]

J. Gordon Millichap, MD, FAAP
Neurology, Children’s Memorial Hospital, Northwestern University Medical School, Chicago, IL