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 Vol. 22 No. 5, November 2009
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AAP Grand Rounds 22:54 (2009)
© 2009 American Academy of Pediatrics

DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Treating Repetitive Behavior in ASD: Citalopram Not Effective

Source: King BH, Hollander E, Sikich L, et al. Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior. Arch Gen Psychiatry. 2009;66(6):583–590; doi:10.1001/archgenpsychiatry.2009.30[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.


PICO

Question: In children with autism spectrum disorders, does citalopram reduce repetitive behaviors?

Question type: Treatment

Study design: Placebo-controlled trial

 

Researchers in the Studies to Advance Autism Research and Treatment (STAART) network undertook a multi-site placebo-controlled 12-week trial to determine if citalopram hydrobromide is effective in treating repetitive behavior in children with autism spectrum disorders (ASD). Citalopram is a selective serotonin reuptake inhibitor (SSRI) that is available in a liquid formulation.

Children and adolescents with ASD of at least moderate severity as rated by the Clinical Global Impressions, Severity of Illness Scale (CGI-I) and who had compulsive . . . [Full Text of this Article]

Alison Schonwald, MD, FAAP
Developmental Medicine Center, Children’s Hospital Boston, Boston, MA