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 Vol. 22 No. 5, November 2009
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AAP Grand Rounds 22:58 (2009)
© 2009 American Academy of Pediatrics

INTERNATIONAL CHILD HEALTH

Ketamine for Elevated Intracranial Pressure

Source: Bar-Joseph G, Guilburd Y, Tamir A, et al. Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension. J Neurosurg Pediatr. 2009;4(1):40–46; doi:10.3171/2009.1.PEDS08319[CrossRef][Medline]

The first 20% of the full text of this article appears below.


PICO

Question: Among mechanically ventilated patients with intracranial hypertension, does administration of ketamine reduce intracranial pressure?

Question type: Intervention

Study design: Prospective, controlled clinical trial.

 

Investigators from Israel prospectively analyzed intracranial pressure (ICP) and hemodynamic responses to ketamine administration in patients aged 1 to 16 years in the pediatric intensive care unit (PICU) with elevated ICP. Ketamine is an anesthetic agent that, in contrast to other sedative and hypnotic agents, does not lower blood pressure. However, ketamine is infrequently used in patients with intracranial hypertension because it is widely believed that it elevates ICP.

Patients with sustained elevated ICP not responsive to first-tier measures were eligible for . . . [Full Text of this Article]

Michael B. Dinerman, MD, FAAP
Piedmont Healthcare, Children’s Healthcare of Atlanta, Atlanta, GA