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 Vol. 22 No. 6, December 2009
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AAP Grand Rounds 22:62 (2009)
© 2009 American Academy of Pediatrics

MEDICAL STUDENTS/RESIDENTS/FELLOWSHIP TRAINEES

PCR Diagnosis of Pertussis

Source: Waters V, Jamieson F, Richardson SE, et al. Outbreak of atypical pertussis detected by polymerase chain reaction in immunized preschool-aged children. Pediatr Infect Dis J. 2009;28(7):582–587; doi:10.1097/INF.0b013e318197fac1[CrossRef][Medline]

The first 20% of the full text of this article appears below.


PICO

Question: Among children aged 0–18 years who have a positive PCR test for pertussis, are there differences in clinical characteristics or risk factors from those with a negative test result?

Question type: Diagnosis

Study design: Retrospective case-control study

 

Investigators from the Hospital for Sick Children in Toronto and the Ontario Agency for Health Protection and Promotion conducted a retrospective case-control study to assess the role of polymerase chain reaction (PCR) in diagnosing Bordetella pertussis infection and to define risk factors for being PCR-positive. Cases were children <18 years old who tested positive for B pertussis by PCR at the Ontario Central Public Health Laboratory (CPHL) during an outbreak of pertussis in 2005–2006. Matched controls were similarly-aged persons from the same region who tested negative for pertussis by PCR. Clinical information on study participants was retrospectively collected by telephone interview of parents and medical record review.

Of 282 eligible cases identified, 189 (67%) were enrolled, 107 were matched to 2 controls, and 82 to 1 control. Of the 189 cases only 5 . . . [Full Text of this Article]

Sarosh Batlivala, MD
Children’s Hospital Boston, Boston, MA