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AAP Grand Rounds 3:3-4 (2000)
© 2000 American Academy of Pediatrics

INFECTIOUS DISEASES

Meningitis, Hib and Pneumococcal Conjugate Vaccines

Sources: (1) Dawson KG, Emerson JC, Burns JL. Fifteen years of experience with bacterial meningitis. Ped Inf Dis J. 1999;18:816–822. (2) Shinefield HR, Black S, Ray P, et al. Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers. Ped Inf Dis J. 1999;18:757–763.

The first 20% of the full text of this article appears below.

Dawson and co-workers assessed the impact of H. influenzae b (Hib) vaccines on bacterial meningitis by examining the changes in the numbers of such infections from 1981–1995 at the Children’s Hospital and Regional Medical Center in Seattle, Washington. This retrospective chart review spanned the 5 years prior to Hib vaccines (1981–1985), 5 years during which unconjugated Hib polysaccharide vaccine was in use (1986–1990), and 5 years after the introduction of conjugate Hib vaccines (1991–1995). The number of cases of Hib meningitis and the percentage of all bacterial meningitis declined from 281 (66%) to 168 (63%) to 14 (12%) during these three 5-year periods. Overall, the number of Hib meningitis cases fell by 95% from . . . [Full Text of this Article]

Leslie Barton, MD, FAAP
Pediatrics and Pediatric Infectious Diseases, University of Arizona, Tucson, AZ