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AAP Grand Rounds 3:7-8 (2000)
© 2000 American Academy of Pediatrics

NEUROLOGY

A New Genetic Marker for Febrile Seizures

Source: Peiffer A, Thompson J, Charlier C, et al. A locus for febrile seizures (FEB3) maps to chromosome 2q23–24. Ann Neurol. 1999;46:671–678.

The first 20% of the full text of this article appears below.

The risk for febrile seizures has been previously shown to have a genetic component.1 To gain a better understanding of this association, linkage analysis genetic studies were conducted at the University of Utah in a four-generation family with 21 members affected by seizures associated with fever and inherited as an autosomal dominant trait. These seizures were generalized, tonic-clonic in pattern and they began between the ages of 5 months and 3 years (mean age, 1.3 years). They were recurrent in 18 patients, some having as many as 16 episodes, but none received antiepileptic medications and none had recurrences beyond 6 years of age (mean age, 4.1 years). Afebrile seizures of various types (generalized tonic-clonic, tonic, atonic, simple or complex partial . . . [Full Text of this Article]

J. Gordon Millichap, MD, FAAP
Neurology, Children’s Memorial Hospital, Northwestern University Medical School, Chicago, IL