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AAP Grand Rounds 3:9-10 (2000)
© 2000 American Academy of Pediatrics

NEPHROLOGY

Transplantation-related Immunosuppression Responsible for EBV-related Disorders

Source: Ellis D, Jaffe R, Green M, et al. Epstein-Barr Virus-related disorders in children undergoing renal transplantation with tacrolimus-based immunosuppression. Transplantation. 1999;68;997–1003.

The first 20% of the full text of this article appears below.

This paper presents a retrospective analysis of Ebstein-Barr (EBV) associated complications in renal transplant patients at the Children’s Hospital of Pittsburgh treated with an immunosuppressive regimen consisting of tacrolimus (FK506) and prednisone between 1989–1987. Pre-transplant EBV status was documented for all recipients and for 72% of the donors. By 1995, it was apparent that EBV represented a significant risk for post-transplant complications and so EBV status was prospectively monitored in all patients from then on. The authors divided the patients into 2 groups. Group I consisted of 51 patients who were transplanted from 1989–95 and group II of 30 patients transplanted after 1995 and in whom EBV studies . . . [Full Text of this Article]

Robert J. Cunningham, III, MD, FAAP
Nephrology, Cleveland Clinic, Cleveland, OH