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AAP Grand Rounds 3:17-18 (2000) Atypical Presentation of SLE Seen in One-third of PatientsSource: Iqbal S, Sher MR, Good RA, et al. Diversity in presenting manifestations of systemic lupus erythematosus in children. J Pediatr. 1999;135:500505.
This is a retrospective study that looks at the presenting manifestations of systemic lupus erythematosus (SLE) in 39 children from All Childrens Hospital, St. Petersburg, Florida. All children with SLE seen at the authors hospital between 1991 and 1998 were described. The age at onset of these patients ranged from 518 years with a median of 12 years. The M:F ratio was 1:18.5 (95% of the children were girls). The ethnic distribution was 41% white, 33% black, and 26% Hispanic (in contrast to the population of the hospitals catchment area which is 89% white). The most common presenting manifestation was musculoskeletal (arthritis, arthralgias, myalgias, and weakness) which occurred in 74% of the children.
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