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AAP Grand Rounds 3:18-19 (2000)
© 2000 American Academy of Pediatrics

ALLERGY AND IMMUNOLOGY

Cow’s Milk Allergy

Source: Saarinen KM, Juntunen-Backman K, Jarvenpaa A-L, et al. Supplementary feeding in maternity hospitals and the risk of cow’s milk allergy: a prospective study of 6209 infants. J Allergy Clin Immunol. 1999;104:457–461.

The first 20% of the full text of this article appears below.

The role of diet in early infancy on the subsequent development of allergy remains controversial. In this study from Finland, 6,209 unselected, healthy, breast-fed, full-term infants were enrolled into a prospective study to determine whether supplementary feeding with cow’s milk formula while in the nursery increased the risk of developing cow’s milk allergy. While in the hospital, 87% (5,385) of the infants required supplemental formula due to insufficient secretion of breast milk. These infants were randomly assigned to receive either cow’s milk formula (1,789 infants), pasteurized pooled human milk (1,859 infants), or whey hydrolysate formula (1,737 infants). The control group of 824 infants was exclusively breast-fed through at least 8 weeks of life. The infants were followed for 18 to 34 months for the development of a suspected cow’s milk allergy. The primary endpoint was a challenge-proven adverse reaction to cow’s . . . [Full Text of this Article]

Robert A. Wood, MD, FAAP
Johns Hopkins Hospital, Baltimore, MD