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AAP Grand Rounds 3:27-28 (2000)
© 2000 American Academy of Pediatrics

CHILDREN WITH DISABILITIES

SPECT Brain Scans for ADHD

Source: Doughtery DD, Bonab AA, Spencer TJ, et al. Dopamine transporter density in patients with attention deficit hyper-activity disorder. Lancet. 1999;354:2132–2133.

The first 20% of the full text of this article appears below.

Pharmacological agents that inhibit the dopamine transporter (such as methylphenidate and dextroamphetamine) are the most effective in ameliorating the symptoms of ADHD. Doughtery et al measured dopamine transporter (DAT1) density in the brain by single photon emission computed tomography (SPECT) with a labeled radioisotope. A 70% increase in DAT1 density was found in patients (6 adults, 4 of whom were females) with attention deficit hyperactivity . . . [Full Text of this Article]

Pasquale Accardo, MD, FAAP
Department of Pediatrics, New York Medical College