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AAP Grand Rounds 3:29 (2000)
© 2000 American Academy of Pediatrics

DERMATOLOGY

Antihistamines Not Proven to Relieve Pruritus in Atopic Dermatitis

Source: Klein PA, Clark RAF. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol. 1999;135:1522–1525.

The first 20% of the full text of this article appears below.

To assess the efficacy of antihistamines in controlling pruritus associated with atopic dermatitis, the authors reviewed all therapeutic trials of sedating and nonsedating agents published between 1966 and 1999. The quality of each study was graded as A (large, randomized, double-blind, placebo-controlled studies that had a low likelihood of false positive or negative results and permitted definitive conclusions and estimates of treatment effect), B (analogous to A but with fewer subjects, thereby increasing the likelihood of . . . [Full Text of this Article]

Daniel P. Krowchuk, MD, FAAP
Pediatrics and Dermatology, Wake Forest University, Winston-Salem, NC