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AAP Grand Rounds 3:41 (2000)
© 2000 American Academy of Pediatrics

SURGERY

Predicting Malignancy in Peripheral Lymphadenopathy

Source: Soldes OS, Younger JG, Hirschi RB. Predictors of malignancy in childhood peripheral lymphadenopathy. J Pediatr Surg. 1999;34:1447–1452.

The first 20% of the full text of this article appears below.

Soldes and colleagues reviewed records of 60 consecutive University of Michigan patients referred for peripheral lymph node biopsy to identify factors that predict malignancy. Fifteen patients were excluded because of a prior diagnosis of cancer or a fluctuant node, leaving 45 patients for final analysis. Increasing risk was found to be associated with larger nodes (greater than 2 cm, Odds Ratio [OR]* 5.8), more than 2 sites of adenopathy (OR*=7.8) and older age (mean age of 12 years for malignant nodes versus 6 years for benign). Additional factors associated with a greater chance of malignancy included supraclavicular adenopathy (OR=10.9), adenopathy on chest x-ray (OR=12.8) and fixed lymph nodes (OR=11.5). The authors found no difference in children with benign versus malignant nodes with regard to the duration of adenopathy, the presence of fever, . . . [Full Text of this Article]

Frederick P. Rivara, MD, FAAP1 and Charles E. Bagwell, MD, FAAP2
1 Pediatrics, University of Washington, Seattle, WA
2 Pediatric Surgery, Medical College of Virginia, Richmond, VA