This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sundarum, R.
Right arrow Articles by Neuspiel, D. R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Sundarum, R.
Right arrow Articles by Neuspiel, D. R.
Related Collections
Right arrow Epidemiology
Right arrow Hematology-Oncology

AAP Grand Rounds 3:45-46 (2000)
© 2000 American Academy of Pediatrics

EPIDEMIOLOGY

Predicting Adverse Outcomes in Sickle Cell Disease

Source: Miller ST, Sleeper LA, Pegelow CH, et al. Prediction of adverse outcomes in children with sickle cell disease. N Engl J Med. 2000;342:83–89.

The first 20% of the full text of this article appears below.

Knowing which children with sickle cell anemia are most likely to develop complications might help pediatricians to tailor therapy, counsel families, and design research studies for new treatments. Miller et al sought to determine early predictors of complications of sickle cell disease in a prospective study of 392 children followed from early infancy to about age 10. In multiple sites across the United States, 414 infants with homozygous sickle cell anemia or sickle cell–ß°-thalassemia were enrolled before age 6 months. Twenty-two (5%) were lost to follow-up. Of 392 remaining children, 70 (18%) had an adverse outcome, defined as death (n=18), stroke (n=25), frequent pain (average of 2 events/year, n=17), or recurrent . . . [Full Text of this Article]

Revathy Sundarum, MD, FAAP1 and Daniel R. Neuspiel, MD, MPH, FAAP2
1 Pediatric Hematology/Oncology, Long Island College Hospital, Brooklyn, NY
2 Pediatrics, Epidemiology and Social Medicine, Albert Einstein College of Medicine and Beth Israel Medical Center, New York, NY