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AAP Grand Rounds 3:49-50 (2000)
© 2000 American Academy of Pediatrics

INFECTIOUS DISEASES

Effect of Intra-Nasal Influenza Vaccine on a Variant Not in the Vaccine

Source: Belshe RB, Gruber WC, Mendelman P. Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine. J Pediatrics. 2000;136:168–175.

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Belshe and colleagues carried out a 2-year, US, multi-center, double-blinded, placebo-controlled efficacy trial of a live attenuated, cold-adapted, trivalent influenza vaccine administered to young children by nasal spray. Subjects were re-vaccinated yearly, and the vaccine was reformulated each year with the same strains used in inactivated influenza vaccines. In year 1 the efficacy of the nasal spray vaccine was 95% (95% CI, 88–97%) against A/H3N2/Wuhan/359/95-like virus. In year 2 the investigators had an opportunity to study the protective efficacy of the nasal spray vaccine against an epidemic influenza A strain that was antigenically different from . . . [Full Text of this Article]

Stanford T. Shulman, MD, FAAP
Pediatric Infectious Diseases, Children’s Memorial Hospital, Northwestern University Medical Center, Chicago, IL