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AAP Grand Rounds 4:11 (2000)
© 2000 American Academy of Pediatrics

GASTROENTEROLOGY AND NUTRITION

Nonalcoholic Steato-hepatitis Associated with Childhood Obesity

Source:Rashid M, Roberts EA.Nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 2000;30:48–53.

The first 20% of the full text of this article appears below.

Non-alcoholic steatohepatitis (NASH) occurs commonly in adults in association with obesity, hyperlipidemia, and adult onset diabetes mellitus1 and is known to be a cause of hepatic fibrosis and cirrhosis.2,3 The natural history and clinical presentation of NASH in children and adolescents is unknown. Rashid and Roberts report their 10-year experience of 36 children (21 male, 15 female) diagnosed with NASH. The median age was 12 years with a range of 4–16 years of age. Thirty patients (83%) were obese, with a mean weight of 147% of ideal body weight. Two patients had diabetes mellitus at the time of diagnosis, while 2 more later developed diabetes . . . [Full Text of this Article]

Michael H. Hart, MD, MS
Division of Gastroenterology, Carilion Health System, Roanoke, VA