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AAP Grand Rounds 4:14-15 (2000)
© 2000 American Academy of Pediatrics

INFECTIOUS DISEASES

The Next Conjugate Vaccine: Meningococcus C

Source: MacLennan JM, Shackley F, Heath PT, et al. Safety, immunogenicity, and induction of immunologic memory by a serogroup C meningococcal conjugate vaccine in infants: a randomized controlled trial. JAMA. 2000;283:2795–2801.

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This British group assessed the safety and immunogenicity of a group C meningococcal conjugate vaccine in young infants. In Oxfordshire, 182 healthy infants were randomized into 2 groups that received meningococcal C conjugate vaccine or to a third control group that received hepatitis B vaccine, each at 2, 3, and 4 months of age as specified in the UK immunization schedule. All three groups concurrently received oral polio vaccine, DTP and Hib which were administered in the child’s other leg. At 12 months, half of each group received a booster dose of the conjugate vaccine and the other half received unconjugated meningococcal group A and C polysaccharide vaccine. Local and systemic reactions were recorded for 6 days after each . . . [Full Text of this Article]

Stanford T. Shulman, MD, FAAP
Pediatric Infectious Diseases, Children’s Memorial Hospital, Northwestern University Medical Center, Chicago, IL

 



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